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Analysis of antifertility activity and phytochemical studies of Pergularia daemia leaves in male albino rats

Ramesh L.Londonkar, Sharangouda J.Patil, Saraswati B.Patil

Petroleumether, benzene and ethanol extracts of Pergularia daemia leaves were administered intraperitoneally at the dose level of 100 and 200mg/kg body weight to male albino rats for 30 days. The results shows decrease in the number of spermatogonia, spermatocytes and spermatids in testis along with spermcount in caudal epididymis. Biochemical observations indicate increased levels of cholesterol and significant reduction in protein and glycogen content. The increased cholesterol content along with degeneration of Leydig cells indicates that inhibited steroidogenesis. The decrease in the weight of a testis and accessory reproductive organs further attributes low steroidogenesis. Out of three extracts tested, ethanol extract was more potent and seems to be antispermatogenic and antisteroidogenic activities.When ethanol extract was tested in immature rats for androgenic activity, it showed its antiandrogenic potency as the weight of accessory sex organs were reduced.