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Checkerboard Method for In Vitro Synergism Testing of Three Antimicrobials against Multidrug-Resistant and Extremely Drug-Resistant Mycobacterium Tuberculosis

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Multi Drug Resistant (MDR) and Extremely Drug Resistant (XDR) Mycobacterium tuberculosis strains pose a significant threat to global public health. The need for effective treatment strategies is imperative. This research explores the application of the checkerboard method for in vitro synergism testing of three antimicrobials against MDR and XDR Mycobacterium tuberculosis. The results demonstrate the potential of combining multiple antimicrobials to enhance therapeutic efficacy and combat drug-resistant tuberculosis.