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Comparative analgesic activity of leaves, stems and roots of Leucas linifolia spreng. (Lamiaceae)

Sneha Anarthe, Rasika Bhalke, Rahul Morjaria, Bhushan Phapale, Sagar Pharande

All the extracts from the leaves, stems and roots of Leucas linifolia (Lamiaceae) were investigated for their analgesic. The effect of pet ether, ethyl acetate and methanol extracts of various parts of Leucas linifolia on nociceptive response using hot plate method and writhing test in mice was examined. All the extracts of Leucas linifolia showed significant central and peripheral analgesic activity in hot plate method and acetic acid-induced writhing test, respectively, at the dose of 50 mg/kg intraperitoneally. Pet ether extract of stems of Leucas linifolia showed highest increase in reaction time in hot plate methodwhilemethanol extract of stems of Leucas linifolia showed more inhibitory effect on writhing induced by acetic acid as compare to extracts of leaves and root.