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Determination of rabeprazole in pharmaceutical formulations by kinetic spectrophotometric method

Amol M.Bhandare, Amol A.Raut, Shitalkumar S.Patil

An important and simple kinetic spectrophotometric method has been developed for the determination of rabeprazole in pharmaceutical formulations. Alkaline potassium permanganate is used in this method for oxidation of rabeprazole at roomtemperature. The increase in the absorbance at 610nm owing to the formation of MnO4 2- was measured spectrophotometrically. Calibration curve procedure was adopted for the assay of the drug. The calibration curve was linear over the concentration ranges of 5- 55g ml-1, with the corresponding calibration equations: Rate = - 410-7 + 8.8410-2C