Abstrato

Development and Evaluation of Multiparticulate Colon Targeted Drug Delivery System

Aboli Nirwane, C. S. Magdum, S. K. Mohite, T. D. Dhughgaonkar, P. P. Hommane and P. S. Kore

A novel colon targeted multiparticles of resveratrol were prepared by solvent evaporation method, using Eudragit S-100 & Eudragit L-100 as polymer. These polymers were pH dependent so that variability in gastric emptying time can be overcome & a colon specific release can be achieved. Different combinations of polymers were selected to achieve suitable lag time for treatment of colon diseases. In-vitro release studies for prepared microparticles were carried out in 0.1 N HCl, 7.4 phosphate buffer and in pH 6.8 phosphate buffer. The morphology of microparticle was studied using scanning electron microscopy and it was observed that microparticle had a spherical shape and smooth surface. The percentage yield of microparticles of all formulation was in the range of 73.89% to 89.57%. The drug content determination showed that even if the polymer composition was changed the solvent evaporation process was highly efficient to give microparticle having maximum drug loading. In conclusion, the prolonged sustained release time and enhanced stability of resveratrol. In vitro studies revealed that multiparticles prepared have limited drug release in stomach and small intestinal environment and release maximum amount of drug in the colonic environment