Abstrato

Effect ofMikania micrantha leaf extract on the level of blood glucose and hepatic glycogen in the normal and alloxan-induced diabetic rats

W.H.Wan Nurhayati, T.NorliArlizan, S.Nurdiana

The present study investigates the hypoglycaemic effect of Mikania micrantha leaf extract in normal and alloxan induced diabetic rats. Male Spargue Dawley rats were used in the study. Oral glucose Tolerence tests (OGTT) was conducted in non-diabetic and alloxan induced diabetic rats using orally administered glucose followed by either the leaf extract or subcutaneous injection of metformin. The fasting blood glucose level ranged from5.15 ± 0.58 mmol/L. The effect of daily oral administration of aqueous extract of Mikania micrantha leaves for a period of 20 days was studied on blood glucose level and hepatic glycogen content in alloxaninduced diabetic rats. Blood glucose level of diabetic rats treated with aqueous extract of Mikania micrantha showed significant reduction (p<0.05) as compared to non- diabetic group. The amount of hepatic glycogen in diabetic rats also was decreased. The observation of this study indicates that the effect of metformin was far more noticeable in diabetic rats. In conclusion, Mikania micrantha has a beneficial effect in the treatment of diabetes mellitus and can form a part of therapy in its management.