Abstrato

Evaluating the reducing properties of some antihypertensive and antibacterial drugs, through their reaction with iron (III) ions

Magda M.Ibrahim, Maha A.Hegazy, Abd El-Aziz El-Bayoumi, Fatma M.Abdel-Gawad, Mohamed A.Abd El-Ghani

In this work the susceptibility of some antihypertensive and antibacterial drugs to oxidation were evaluated and compared through the application of a spectrophotometric method. Irbesartan (IRB), valsartan (VAL) and lisinopri l (LSP) were selected as an example of antihypertensives, while two antibacterial drugs namely, cefixime (CFX) and cefprozil (CFP) were investigated. The applied method was based on the reaction of the cited drugs with iron (III) ions as an oxidizing agent. The resulted iron (II) ions reacted with o-phenanthroline forming the well-known highly stable orange-red colored chelate complex, which exhibits an absorption maximum at 510 nm. Different conditions were thoroughly studied and optimized. The reducing properties of the selected drugs were compared to each other (under the applied experimental conditions) and results show that these drugs act as reducing agents in the following order; CFP>CFX>IRB>LSP>VAL. The method was applied in a trial to investigate the stability of these drugs in air and results showed that cefprozil, cefixime and irbesartan are very labile to autoxidation.