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In-vitro release test of hydroxyapatite/collagen/polylactide reservoir controlled-release drug carrier

ZhenlinWang, Yuhua Yan, TaoWan

In order to explore the characteristics of release rate of Hydroxyapatite/ collagen/polylactide (HAp/Col/PLLA) reservoir controlled-release drug carrier, biomimetic bone-like hadroxyapatite/collagen (HAp/Col) composite was prepared by co-precipitation, 3-Dporous reservoir control-released drug carrier was further synthesized with polylactide by thermal-induced phase separation plus non-solvent extraction pore-leaching technique. In vitro control release testwas performed using bromothymol blue (BTB) asmodel compound and phosphate buffer as stimulated body fluid, the release mechanism is demonstrated through an analysis of a drug-release model. The results show that the pore size of the carrier was in the range of 50- 100ìm in diameter; BTB released at a stable rate during the 80% releasing period, the release process can appropriately be regarded as zero order release and the as-prepared carrier principally achieved a consistent controlled release state.