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Microwave Assisted Synthesis of Some New Spiro-[indole-thiazolidine] Derivatives : A Green Chemical Pathway

Kirti Shrimali, Manish Rawal, Pinki B. Punjabi and Suresh C. Ameta

The reaction sequence involves microwave induced preparation of N-(2-oxo-1, 2-dihydro-3’Hindol-3-ylidene) pyridine-4-carbohydrazide (3) from isoniazid (1) and isatin (2) followed by the cyclocondensation of (3) and mercaptoacetic acid under microwave conditions to achieve the synthesis of spiro-[indole-thiazolidine] compound (4). The resulting compound was then allowed to react with various aromatic aldehydes to afford arylidene derivatives (5a-d).