Abstrato

Preventive Effect of Vanillin on Lipid Peroxides and Antioxidants in Potassium Bromate-Induced Cardiotoxicity in Adult Mice: Biochemical and Histopathological Evidences

Saad HB , Amara IB , Boudawara T and Hakim A

Potassium bromate (KBrO3) is a xenobiotic which causes several diseases. Our experimental objective was designed to evaluate the cardioprotective potential of vanillin on lipid peroxides, enzymatic and nonenzymatic antioxidants and histopathological findings in KBrO3-induced cardiotoxicity in adult mice. The oral administration of KBrO3 (2 g/L) to adult mice showed a significant increase in lipid peroxidation and advanced oxidation protein product levels in the heart, and a significant decrease in the superoxide dismutase, catalase, glutathione peroxidase activities and the levels of reduced glutathione in the heart. The daily administration of vanillin (100 mg/kg by intraperitonial injection) to KBrO3-induced mice for a period of 15 days showed a significant decrease in the levels of lipid peroxidation and protein oxidation, and improved the antioxidant status by increasing the activities of antioxidant enzymes and nonenzymatic antioxidants. The histopathological findings of the myocardial tissue showed the protective role of vanillin in KBrO3-induced mice. The results of our study showed that vanillin possesses anti-lipoperoxidative and antioxidant activites in experimentally KBrO3-induced cardiac toxicity.