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Protective effect of Agrimonia eupatoria L. against chemical-induced hepatotoxicity

Se Chan Kang, Jong Phil Bak, Hyun Woo Kim, Eui Su Choung, Min Kyung Lee, Jong Hwan Kwak, Tae Rim Kim, In Gyu Kim, Ok Pyo Zee

The hepatoprotective activities of Agrimonia eupatoria L. extract were assessed by measuring hematological and serological levels in SD rats following chemical-induced liver injury. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were dose-dependently decreased in carbon tetrachloride (CCl4) and D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury in rats. These results revealed significant, dose-dependent hepatoprotective potential for A.eupatoria extract as it restored the majority of abnormal hepatic parameters in experimental liver damage in rats; it may therefore be useful in recovery of liver disorders.