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Role of methanol extract of Andrographis paniculata nees on chromium induced alteration of functional status of liver in male albino rats

Sankar Kumar Dey, Krishnendu Bikash Karmakar, Sukhendu Jana

Occupational exposure to Chromium(Cr) compounds provides the primary source of information on Cr toxicity and carcinogenicity in humans.Methanol extract of Andrographis paniculata, a hepato protectant may be used to reduce the Cr-induced liver impairment in maleWistar rats. To know the functional status of liver, we determined the activities of ALP, SGOT and SGPT and the contents of total bilirubin, direct bilirubin, albumin, total protein and serum glucose. TheALP, SGOT and SGPT activities were significantly higher in response to chromium (0.8 mg per 100 g body weight, i.p., for a period of 7 days). On the other hand, the levels of total bilirubin, direct bilirubin, albumin, total protein and serumglucose were lower in Crtreated rats. Alteration of these parameters indicates that continuous accumulation of chromiummay cause the liver impairment by the generation of free radicals. However, Methanol extract of Andrographis paniculata (100mg per kg bodyweight daily at an interval of 3 h after injection of Cr for a period of 7 days) supplementation restored the alterations of liver impairment induced by Cr.