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Simultaneous Estimation Of Paracetamol, Aceclofenac And Chlorzoxazone In Oral Dosage Form Using Spectrophotometric Method

N.Harikrishnan, K.Kalaivani, Vijay Kumar Meher, V.Gunasekaran, A.Sathish Babu, C.Roosewelt

A simple, fast and precise multicomponent mode analysis method has been developed for the simultaneous determination of paracetamol, aceclofenac and chlorzoxazone in combined tablet dosage form. Shimadzu UV-1700 instrument was used and the max of paracetamol, aceclofenac and chlorzoxazone was found to be 247nm, 275nm and 282nm using methanol as a solvent and linearity lies between 1-12g/ml for paracetamol, 1-28 cg/ml for aceclofenac and 1-30g/ml for chlorzoxazone at their respective wavelengths. Amount found for paracetamol, aceclofenac and chlorzoxazone were found to be 519.95, 100.80 and 498.57g/tablet respectively. Percentage recovery range was found to be within 99.74-101.30% for paracetamol, 99.52-101.80% for aceclofenac, 99.23-101.35% for chlorzoxazone.