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Simultaneous estimation of rabeprazole sodium and levosulpiride by UV-spectrophotometry in tablet formulation

Sanjay Sudhakar Pekamwar, Tukaram Mohanrao Kalyankar, Moein Sharfodin Attar

A new, simple, economic, rapid and novel spectrophotometric method has been developed for simultaneous estimation of Rabeprazole Sodium (RAB) and Levosulpiride LEV. Simultaneous equation method is used. The method involves measurement of absorbance at wavelengths, 284 nm and 232 nm, ëmax of RAB and LEV respectively. RAB and LEVobeys BeerÂ’s law obeyed in concentration range of 4-24 ìg/ mL and 15-45 ìg/ mL respectively. The proposedmethod is recommended for routine analysis since it is rapid, simple, accurate, precise, sensitive and specific. This paper describes the development and validation of UV spectroscopic method for Simultaneous estimation of RAB and LEV in combined tablet dosage form.