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Spectrophotometric Determination of Cisapride in Pharmaceutucal Formulations

K. Prabhavathi, T. Sreenivasulu Reddy, G. Abdul Huq and N. Rami Reddy

A simple and economical spectrophotometric method has been developed for the assay of cisaprode in pharmaceutical formulations. The method is based on the formation of a wine red coloured azo product by the diazotization of cisapride followed by a coupling reaction with p-hydroxy acetanilide. The absorbance of wine red coloured azo product is measured at 498 nm against reagent blank. Beer’s law is obeyed in the concentration of 40-200 μg/mL of drug.