Abstrato

Spectrophotometric Method for the Determination of Simvastatin in Pharmaceutical Dosage Forms

S. Vijaya Saradhi, G. Devala Rao, B. Sitaram, K. Pravallika, P. Amulya Chowdary and V. Sindhu

A simple, sensitive and reproducible spectrophotmetric method has been developed for the determination of simvastatin in bulk and dosage forms. This method is based on the formation of colour species on binding of simvastatin with the ligand ferric nitrate and concentrated nitric acid to produce yellowish green colored solution ( max at 390 nm). Results of analysis were validated statistically and by recovery studies. This method is successfully employed for the determination of simvastatin in various pharmaceutical preparations.