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Telomerase as a tumor marker in hepatocellular carcinoma

Wisam Abd El-Moaty Kolab


This study was conducted on 25 healthy controls, 25 cirrhotic patients and 30 patients with HCC. All patients had been diagnosed with HCVassociated chronic liver disease.Methods: SerumPIVKA-II andAFPwere measured by enzyme linked immunosorbent assay (ELISA), while telomerase activity in peripheral blood was estimated by polymerase chain reaction- enzyme- linked immunosorbent assay (PCR- ELISA method). Results: Mean telomerase activity, PIVKA-II and AFP levels were significantly higher in HCC patients as compared to both cirrhotic patients and controls, also a significant elevation in cirrhotic patients were found as compared to controls. Positive correlation was found between telomerase activity and size of hepatic focal lesions. Also, a positive correlation was found between both telomerase activity and PIVIKA-II and between the pathological grades of HCC. In HCC the sensitivity/ specificity (88.2/79.6) of telomerase activity was much higher than both PIVIKA-II (80.5/69.3) andAFP (72.6/61.5). Conclusion: The usefulness of telomerase activity assay in HCC diagnosis and itÂ’s superiority to other tumor marker were recorded. Therefore, telomerase activity is a novel, available detector and prognostic marker for HCC diagnosis.


Indexado em

  • CASS
  • Google Scholar
  • Abra o portão J
  • Infraestrutura Nacional de Conhecimento da China (CNKI)
  • CiteFactor
  • Cosmos SE
  • Biblioteca de Periódicos Eletrônicos
  • Diretório de indexação de periódicos de pesquisa (DRJI)
  • Laboratórios secretos de mecanismos de pesquisa
  • ICMJE

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